Article
Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179.
Nature communications - 23 Jan 2015
Nishiguchi Koji M, Carvalho Livia S, Rizzi Matteo, Powell Kate, Holthaus Sophia-Martha kleine, Azam Selina A, Duran Yanai, Ribeiro Joana, Luhmann Ulrich F O, Bainbridge James W B, Smith Alexander J, Ali Robin R
Abstract excerpt
The rd1 mouse with a mutation in the Pde6b gene was the first strain of mice identified with a retinal degeneration. However, AAV-mediated gene supplementation of rd1 mice only results in structural preservation of photoreceptors, and restoration of the photoreceptor-mediated a-wave, but not in restoration of the bipolar cell-mediated b-wave. Here we show that a mutation in Gpr179 prevents the full restoration of...
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