Article

AAV8-PDE6B with 3’UTR provides durable rescue of photoreceptor structure and function in rd10 mouse model of retinitis pigmentosa

2026-05-20

Abstract excerpt

<title>Abstract</title> <p> Retinitis pigmentosa (RP), a leading cause of inherited blindness, often results from phosphodiesterase 6 (PDE6) deficiency. We evaluated a novel gene therapy construct, AAV8-RK-PDE6B-3’UTR, in the <italic>rd10</italic> mouse model which lacks the functional β-subunit of PDE6. The construct utilises a rhodopsin-kinase promoter, human PDE6B cDNA, and a PDE6B 3’ untranslated region (3...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 674950ed-2c4b-5a84-ae3f-4e5e72ad905c
DOI: 10.21203/rs.3.rs-9298568/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

AAV8-PDE6B with 3’UTR provides durable rescue of photoreceptor structure and function in rd10 mouse model of retinitis pigmentosaDOI 10.21203/rs.3.rs-9298568/v1Read

Review: the history and role of naturally occurring mouse models with Pde6b mutations.Semantic proximity Read

Gene therapy provides long-term visual function in a pre-clinical model of retinitis pigmentosaSemantic proximity Read

AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation.Semantic proximity Read

Long-term Retinal Function and Structure Rescue Using Capsid Mutant AAV8 Vector in the rd10 Mouse, a Model of Recessive Retinitis PigmentosaSemantic proximity Read

Subretinal delivery of AAV5-mediated human Pde6b gene ameliorates the disease phenotype in a rat model of retinitis pigmentosa.Semantic proximity Read

Gene Supplementation Rescues Rod Function and Preserves Photoreceptor and Retinal Morphology in Dogs, Leading the Way Toward Treating Human PDE6A -Retinitis PigmentosaSemantic proximity Read

Advancing Gene Therapy for PDE6A Retinitis Pigmentosa.Semantic proximity Read

A gene-augmentation framework for selected early-stage autosomal recessive retinitis pigmentosa genotypesSemantic proximity Read

Therapeutic Margins in a Novel Preclinical Model of Retinitis PigmentosaSemantic proximity Read

Navigating the future of retinitis pigmentosa treatments: A comprehensive analysis of therapeutic approaches in rd10 miceSemantic proximity Read

<i>In vivo</i> base editing rescues photoreceptors in a mouse model of retinitis pigmentosaSemantic proximity Read

AAV-mediated Gene Therapy Halts Retinal Degeneration in PDE6β-deficient DogsSemantic proximity Read