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Article

A New Mouse Model for Complete Congenital Stationary Night Blindness Due to Gpr179 Deficiency.

International journal of molecular sciences - 23 Apr 2021

Orhan Elise, Neuillé Marion, de Sousa Dias Miguel, Pugliese Thomas, Michiels Christelle, Condroyer Christel, Antonio Aline, Sahel José-Alain, Audo Isabelle, Zeitz Christina

Abstract excerpt

Mutations in GPR179 lead to autosomal recessive complete congenital stationary night blindness (cCSNB). This condition represents a signal transmission defect from the photoreceptors to the ON-bipolar cells. To confirm the phenotype, better understand the pathogenic mechanism in vivo, and provide a model for therapeutic approaches, a Gpr179 knock-out mouse model was genetically and functionally characterized. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33922602
DOI: 10.3390/ijms22094424
PMCID: PMC8122890

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A New Mouse Model for Complete Congenital Stationary Night Blindness Due to Gpr179 Deficiency.PMID 33922602Read ↗

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