Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Presence of the Gpr179(nob5) allele in a C3H-derived transgenic mouse.

Molecular vision - 1 Jan 2013

Balmer Jasmin, Ji Rui, Ray Thomas A, Selber Fabia, Gassmann Max, Peachey Neal S, Gregg Ronald G, Enzmann Volker

Abstract excerpt

PURPOSE: To identify the mutation responsible for an abnormal electroretinogram (ERG) in a transgenic mouse line (tg21) overexpressing erythropoietin (Epo). The tg21 line was generated on a mixed (C3H; C57BL/6) background and lacked the b-wave component of the ERG. This no-b-wave (nob) ERG is seen in other mouse models with depolarizing bipolar cell (DBC) dysfunction and in patients with the complete form of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electroretinography
Share to Erythropoietin
Share to Founder Effect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C3H

Share to Mutagenesis, Insertional

Share to Night Blindness

Share to Receptors, G-Protein-Coupled

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 24415894
PMCID: PMC3883591

Genes

ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Presence of the Gpr179(nob5) allele in a C3H-derived transgenic mouse.PMID 24415894Read ↗

Survey of the nob5 mutation in C3H substrains.Semantic proximity Read ↗

GPR179 is required for depolarizing bipolar cell function and is mutated in autosomal-recessive complete congenital stationary night blindness.Semantic proximity Read ↗

A New Mouse Model for Complete Congenital Stationary Night Blindness Due to Gpr179 Deficiency.Semantic proximity Read ↗

Transgenic mice carrying the H258N mutation in the gene encoding the beta-subunit of phosphodiesterase-6 (PDE6B) provide a model for human congenital stationary night blindness.Semantic proximity Read ↗

Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179.Semantic proximity Read ↗

Severe retinal degeneration caused by a novel rhodopsin mutation.Semantic proximity Read ↗

Genotypic and phenotypic characterization of P23H line 1 rat model.Semantic proximity Read ↗

Generation, identification and functional characterization of the nob4 mutation of Grm6 in the mouse.Semantic proximity Read ↗

Mutations within the cGMP-binding domain of CNGA1 causing autosomal recessive retinitis pigmentosa in human and animal modelSemantic proximity Read ↗

The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes.Semantic proximity Read ↗

Novel Grm6 Variant in a no b-wave (nob) Mouse Model: Phenotype Characterization and Gene Therapy.Semantic proximity Read ↗

Characterization of a dominant cone degeneration in a green fluorescent protein-reporter mouse with disruption of Loci associated with human dominant retinal dystrophy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.