The Distribution of Apolipoprotein E Genotype Over The Adult Lifespan and in Relation to Country of Birth

Abstract excerpt

Apolipoprotein E (ApoE) is encoded by the codominant alleles ε2, ε3, and ε4, resulting in 6 bi-allelic genotypes (1–4). The corresponding protein isoforms differ in their lipoprotein receptor affinity, antioxidant activity, and inflammation modulatory properties (1, 5–8). APOE ε4 carriership is associated with an increased risk of atherosclerosis and dementia (9). Approximately 65%–75% of patients with...

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