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Article

Developmental- and differentiation-specific patterns of human γ- and β-globin promoter DNA methylation

25 Apr 2007

Abstract excerpt

The mechanisms underlying the human fetal-to-adult beta-globin gene switch remain to be determined. While there is substantial experimental evidence to suggest that promoter DNA methylation is involved in this process, most data come from studies in nonhuman systems. We have evaluated human gamma- and beta-globin promoter methylation in primary human fetal liver (FL) and adult bone marrow (ABM) erythroid cells....

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Share to Epigenetics and DNA Methylation
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PMID: 17456718
DOI: 10.1182/blood-2007-01-068635

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