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Dissecting the epigenetic regulation of the fetal hemoglobin genes to unravel a novel therapeutic approach for β-hemoglobinopathies

18 Jun 2025

Abstract excerpt

Beta-hemoglobinopathies are severe genetic diseases caused by mutations affecting the production of the adult β-globin chain. The clinical severity is mitigated by the co-inheritance of mutations that reactivate the production of the fetal β-like γ-globin in adults. However, the epigenetic mechanisms underlying the adult-to-fetal hemoglobin (HbA-to-HbF) switching are still not fully understood. Here, we used...

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Share to Epigenetics and DNA Methylation
Share to Hemoglobinopathies and Related Disorders
Share to Prenatal Screening and Diagnostics

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PMID: 40637230
DOI: 10.1093/nar/gkaf637

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