Article
Copy number variations are progressively associated with the pathogenesis of colorectal cancer in ulcerative colitis.
World journal of gastroenterology - 14 Jan 2015
Shivakumar Bhadravathi Marigowda, Rotti Harish, Vasudevan Thanvanthri Gururajan, Balakrishnan Aswath, Chakrabarty Sanjiban, Bhat Ganesh, Rao Lakshmi, Pai Cannanore Ganesh, Satyamoorthy Kapaettu
Abstract excerpt
AIM: To evaluate the association of known copy number variations (CNVs) in ulcerative colitis (UC) progressing to colorectal cancer. METHODS: Microsatellite instability analysis using the National Cancer Institute's panel of markers, and CNV association studies using Agilent 2 × 105 k arrays were done in tissue samples from four patient groups with UC: those at low risk (LR) or high risk of developing colorectal...
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