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Article

PKA catalytic subunit mutations in adrenocortical Cushing's adenoma impair association with the regulatory subunit.

Nature communications - 5 Dec 2014

Calebiro Davide, Hannawacker Annette, Lyga Sandra, Bathon Kerstin, Zabel Ulrike, Ronchi Cristina, Beuschlein Felix, Reincke Martin, Lorenz Kristina, Allolio Bruno, Kisker Caroline, Fassnacht Martin, Lohse Martin J

Abstract excerpt

We recently identified a high prevalence of mutations affecting the catalytic (Cα) subunit of protein kinase A (PKA) in cortisol-secreting adrenocortical adenomas. The two identified mutations (Leu206Arg and Leu199_Cys200insTrp) are associated with increased PKA catalytic activity, but the underlying mechanisms are highly controversial. Here we utilize a combination of biochemical and optical assays, including...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25477193
DOI: 10.1038/ncomms6680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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