Enumeration and targeted analysis of KRAS, BRAF and PIK3CA mutations in CTCs captured by a label-free platform: Comparison to ctDNA and tissue in metastatic colorectal cancer.

doi:10.18632/oncotarget.13350

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Article

Enumeration and targeted analysis of KRAS, BRAF and PIK3CA mutations in CTCs captured by a label-free platform: Comparison to ctDNA and tissue in metastatic colorectal cancer.

Oncotarget - 20 Dec 2016

Kidess-Sigal Evelyn, Liu Haiyan E, Triboulet Melanie M, Che James, Ramani Vishnu C, Visser Brendan C, Poultsides George A, Longacre Teri A, Marziali Andre, Vysotskaia Valentina, Wiggin Matthew, Heirich Kyra, Hanft Violet, Keilholz Ulrich, Tinhofer Ingeborg, Norton Jeffrey A, Lee Mark, Sollier-Christen Elodie, Jeffrey Stefanie S

Abstract excerpt

Treatment of advanced colorectal cancer (CRC) requires multimodal therapeutic approaches and need for monitoring tumor plasticity. Liquid biopsy biomarkers, including CTCs and ctDNA, hold promise for evaluating treatment response in real-time and guiding therapeutic modifications. From 15 patients with advanced CRC undergoing liver metastasectomy with curative intent, we collected 41 blood samples at different...

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Identifiers

PMID: 27863403
DOI: 10.18632/oncotarget.13350
PMCID: PMC5356741

Genes

BRAF
KRAS

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Source receipt: pubmed, retrieved 7 Sept 2026.

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