Article
Detection of KRAS mutations in circulating tumor cells from patients with metastatic colorectal cancer.
Cancer biology & therapy - 1 Jan 2015
Buim Marcilei Ec, Fanelli Marcello F, Souza Virgilio S, Romero Juliana, Abdallah Emne A, Mello Celso Al, Alves Vanessa, Ocea Luciana Mm, Mingues Natália B, Barbosa Paula Nvp, Tyng Chiang J, Chojniak Rubens, Chinen Ludmilla Td
Abstract excerpt
BACKGROUND: Quantification of Circulating Tumor Cells (CTCs) as a prognostic marker in metastatic colorectal cancer (mCRC) has already been validated and approved for routine use. However, more than quantification, qualification or characterization of CTCs is gaining importance, since the genetic characterization of CTCs may reflect, in a real time fashion, genetic profile of the disease. OBJECTIVE: To...
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