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Article

The role of the maternal immune system in the regulation of human birthweight.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 5 Mar 2015

Moffett Ashley, Hiby Susan E, Sharkey Andrew M

Abstract excerpt

Human birthweight is subject to stabilizing selection. Large babies are at risk of obstetric complications such as obstructed labour, which endangers both mother and child. Small babies are also at risk with reduced survival. Fetal growth requires remodelling of maternal spiral arteries to provide an adequate maternal blood supply to the placenta. This arterial transformation is achieved by placental trophoblast...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25602075
DOI: 10.1098/rstb.2014.0071
PMCID: PMC4305172

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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