Article
Associations between fetal HLA-G genotype and birth weight and placental weight in a large cohort of pregnant women - Possible implications for HLA diversity.
Journal of reproductive immunology - 1 Apr 2017
Emmery Johanne, Christiansen Ole B, Nilsson Line Lynge, Dahl Mette, Skovbo Peter, Møller Anna Margrethe, Steffensen Rudi, Hviid Thomas Vauvert F
Abstract excerpt
Birth weight and placental weight are crucial parameters for the survival of fetuses and newborns in mammals. High variation in the MHC is important for an effective adaptive immune response. The maternal immune system must be controlled in relation to the semi-allogenic fetus. The immunoregulatory HLA/MHC class Ib gene, HLA-G, is strongly expressed on extravillous trophoblast cells. We investigated birth weight...
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