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Article

Examining the association between fetal HLA-C, maternal KIR haplotypes and birth weight.

PLoS genetics - 1 Apr 2026

Decina Caitlin Stephanie, Warrington Nicole M, Beaumont Robin N, Bian Beilei, Brito Nunes Caroline, Wang Geng, Lowe William L, Squire David, Vukcevic Damjan, Leslie Stephen, Freathy Rachel M, Evans David M

Abstract excerpt

Human birth weight is under stabilizing selection, seeking balance between extremes of high and low, thereby reducing fetal and maternal perinatal mortality risk. Certain combinations of maternal killer immunoglobulin-like receptor (KIR) and paternally derived fetal human leuokocyte antigen-C (HLA-C) alleles were previously associated with higher risk of high and low birth weight in a study with limited sample...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42008539
DOI: 10.1371/journal.pgen.1012102
PMCID: PMC13095029

Genes

C2
KIR2DS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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