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Article

Cylindromatosis (Cyld) gene mutation in T cells promotes the development of an IL-9-dependent allergic phenotype in experimental asthma.

Cellular immunology - 1 Oct 2016

Reuter Sebastian, Maxeiner Joachim, Meyer-Martin Helen, Michel Anastasija, Baars Pamela, Bopp Tobias, Waisman Ari, Reissig Sonja, Wehler Thomas C, Schild Hansjörg, Taube Christian, Stassen Michael, Becker Marc

Abstract excerpt

Cylindromatosis (CYLD) is a ubiquitously expressed deubiquitinating enzyme which removes activating ubiquitin residues from important signaling molecules of the NF-κB pathway. In CYLDex7/8 transgenic mice, a naturally occurring short isoform (sCYLD) is overexpressed in the absence of full length CYLD, leading to excessive NF-κB activity. Herein, we investigated the impact of the CYLDex7/8 mutation selectively in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27372382
DOI: 10.1016/j.cellimm.2016.06.003

Genes

CYLD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cylindromatosis (Cyld) gene mutation in T cells promotes the development of an IL-9-dependent allergic phenotype in experimental asthma.PMID 27372382Read ↗

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