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Article

The Role of Proteasomes in the Thymus.

Frontiers in immunology - 1 Jan 2021

Frantzeskakis Melina, Takahama Yousuke, Ohigashi Izumi

Abstract excerpt

The thymus provides a microenvironment that supports the generation and selection of T cells. Cortical thymic epithelial cells (cTECs) and medullary thymic epithelial cells (mTECs) are essential components of the thymic microenvironment and present MHC-associated self-antigens to developing thymocytes for the generation of immunocompetent and self-tolerant T cells. Proteasomes are multicomponent protease...

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Source

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Identifiers

PMID: 33815406
DOI: 10.3389/fimmu.2021.646209
PMCID: PMC8017227

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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