Article

Common and Mutation Specific Phenotypes of KRAS and BRAF Mutations in Colorectal Cancer Cells Revealed by Integrative-Omics Analysis

2021-04-26

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Genes in the Ras pathway have somatic mutations in at least 60 % of colorectal cancers. Despite activating the same pathway, the <italic>BRAF</italic> V600E mutation and the prevalent mutations in codon 12 and 13 of <italic>KRAS</italic> have all been linked to different clinical outcomes, but the molecular mechanisms behind these differences largely remain to be...

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Literature Corpus work: b17edbc3-fe57-5340-9e92-e5abdb4d0ffe
DOI: 10.21203/rs.3.rs-397255/v1

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