Article
Novel prognostic molecular factors: a quantum leap in the field of chronic lymphocytic leukemia.
Folia histochemica et cytobiologica - 1 Jan 2017
Zakrzewska Ewelina, Pirog Marta, Purkot Joanna, Giannopoulos Krzysztof
Abstract excerpt
Cytogenetic lesions do not completely explain clinical heterogeneity of chronic lymphocytic leukemia (CLL). The 2016 revision of the World Health Organization classification 2008 indicated that molecular lesions of TP53, NOTCH1, SF3B1 and BIRC3 have potential clinical relevance and could be integrated into an updated risk profile. The negative clinical implications of TP53 disruptions are well constituted and...
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