The pathologic and genomic evolution of primary malignant phyllodes tumors of the breast: retrospective cohort study and case-control genomic analysis.

doi:10.1093/oncolo/oyaf012

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Article

The pathologic and genomic evolution of primary malignant phyllodes tumors of the breast: retrospective cohort study and case-control genomic analysis.

The oncologist - 6 Feb 2025

Valenza Carmine, Trapani Dario, Porta Francesca Maria, Olmeda Edoardo, Gaeta Aurora, Boscolo Bielo Luca, Conversano Federica, De Pas Tommaso Martino, Castellano Grazia, Santoro Celeste, Battaiotto Elena, Mane Eltjona, Coppola Sara, Conforti Fabio, Mattar Denise, Gandini Sara, Veronesi Paolo, Guerini Rocco Elena, Pennacchioli Elisabetta, Curigliano Giuseppe

Abstract excerpt

BACKGROUND: In patients with phyllodes tumors of the breast, the presence of mediator of RNA polymerase II transcription subunit 12 homolog mutations (MED12m) and a history of previous fibroadenoma may predict better outcomes. To aid in the prognostication of malignant phyllodes tumors of the breast (B-MPT), we assessed the prognostic value of fibroadenoma-like areas (supposed to have stemmed from a pre-existing...

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PMID: 39921370
DOI: 10.1093/oncolo/oyaf012
PMCID: PMC11806198

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MED12

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The pathologic and genomic evolution of primary malignant phyllodes tumors of the breast: retrospective cohort study and case-control genomic analysis.PMID 39921370Read ↗

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