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Article

Basolateral secretion of Wnt5a in polarized epithelial cells is required for apical lumen formation.

Journal of cell science - 1 Mar 2015

Yamamoto Hideki, Awada Chihiro, Matsumoto Shinji, Kaneiwa Tomoyuki, Sugimoto Takayuki, Takao Toshifumi, Kikuchi Akira

Abstract excerpt

Wnt5a regulates planar cell polarity in epithelial cells, but it remains to be determined whether Wnt5a and its receptors are sorted apically or basolaterally, and how Wnt5a signaling is involved in apical and basolateral polarization. We found that Wnt5a was secreted basolaterally in polarized kidney epithelial cells. The basolateral secretion of Wnt5a required Wntless (Wls), clathrin and adaptor protein 1...

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Identifiers

PMID: 25593127
DOI: 10.1242/jcs.163683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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