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Coordination of kidney organogenesis by Wnt signaling

20 Jan 2014

Abstract excerpt

Several Wnt proteins are expressed in the embryonic kidney during various stages of development. Gene knockout models and ex vivo studies have provided strong evidence that Wnt-mediated signals are essential in renal ontogeny. Perhaps the most critical factors, Wnt9b and Wnt4, function during the early phase when the cap mesenchyme is induced to undergo morphogenesis into a nephron. Wnt11 controls early ureteric...

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PMID: 24445433
DOI: 10.1007/s00467-013-2733-z

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