Galectin-4-mediated transcytosis of transferrin receptor.

doi:10.1242/jcs.153437

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Article

Galectin-4-mediated transcytosis of transferrin receptor.

Journal of cell science - 15 Oct 2014

Perez Bay Andres E, Schreiner Ryan, Benedicto Ignacio, Rodriguez-Boulan Enrique J

Abstract excerpt

Some native epithelia, for example, retinal pigment epithelium (RPE) and kidney proximal tubule (KPT), constitutively lack the basolateral sorting adaptor AP-1B; this results in many basolateral plasma membrane proteins being repositioned to the apical domain, where they perform essential functions for their host organs. We recently reported the underlying apical polarity reversal mechanism: in the absence of...

Topics

Adaptor Protein Complex 1
Adaptor Protein Complex beta Subunits
Animals
Cell Line
Cell Membrane
Cell Polarity
Dogs
Endosomes
Epithelial Cells
Galectin 4
Gene Knockdown Techniques
Humans
Lysosomes
Madin Darby Canine Kidney Cells
Mutation
Protein Sorting Signals
Protein Transport
Receptors, Transferrin

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PMID: 25179596
DOI: 10.1242/jcs.153437
PMCID: PMC4197088

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