Article
Reciprocal inhibition of Wnt signaling pathways pattern the interconnection of epithelial tubules in the regenerating zebrafish kidney.
Development (Cambridge, England) - 15 Feb 2026
Kamei Caramai N, Sampson William G B, Albertz Carolin, Aries Oliver, Wolf Amber, Upadhyay Rohan M, Hughes Samuel M, Schenk Heiko, Bonnet Frederic, Draper Bruce B W, McCracken Kyle W, Marciano Denise K, Oxburgh Leif, Drummond Iain A
Abstract excerpt
In the adult zebrafish kidney, nephrogenesis occurs as a regenerative response to injury and provides a model to explore cell signaling pathways required for nephron formation and engraftment. Differentiating kidney tubules interconnect with collecting system epithelia to generate a pathway for fluid excretion. We show that canonical Wnt signaling induces a mesenchymal, invasive cell phenotype and is required,...
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