Article

Network-based representation learning enables the identification of risk genes and latent functional pathways in primary open-angle glaucoma

2024-08-19

Abstract excerpt

<h4>ABSTRACT</h4> Despite the identification of hundreds of risk genes for primary open-angle glaucoma (POAG), a significant portion of the POAG genetic risk landscape remains unexplored. We hypothesized that unsupervised learning on large protein-protein interaction (PPI) networks could enable comprehensive characterization of the genetic pathways that underlie POAG risk. We used graph representation learning on...

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Literature Corpus work: c9049be2-c94e-51d8-acec-7660ae790a60
DOI: 10.1101/2024.08.15.608134

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