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Article

Reduced susceptibility to induced seizures in the Neuroligin-3(R451C) mouse model of autism.

Neuroscience letters - 4 Mar 2015

Hill-Yardin Elisa L, Argyropoulos Andrew, Hosie Suzanne, Rind Gil, Anderson Paul, Hannan Anthony J, O'Brien Terence J

Abstract excerpt

Epilepsy is a common comorbidity in patients with autism spectrum disorder (ASD) and several gene mutations are associated with both of these disorders. In order to determine whether a point mutation in the gene for the synaptic protein, Neuroligin-3 (Nlgn3, R451C), identified in patients with ASD alters seizure susceptibility, we administered the proconvulsant pentylenetetrazole (PTZ) to adult male...

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Identifiers

PMID: 25592157
DOI: 10.1016/j.neulet.2015.01.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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