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Article

A long-acting integrase inhibitor protects female macaques from repeated high-dose intravaginal SHIV challenge.

Science translational medicine - 14 Jan 2015

Andrews Chasity D, Yueh Yun Lan, Spreen William R, St Bernard Leslie, Boente-Carrera Mar, Rodriguez Kristina, Gettie Agegnehu, Russell-Lodrigue Kasi, Blanchard James, Ford Susan, Mohri Hiroshi, Cheng-Mayer Cecilia, Hong Zhi, Ho David D, Markowitz Martin

Abstract excerpt

Long-acting GSK1265744 (GSK744 LA) is a strand transfer inhibitor of the HIV/SIV (simian immunodeficiency virus) integrase and was shown to be an effective preexposure prophylaxis (PrEP) agent in a low-dose intrarectal SHIV (simian-human immunodeficiency virus) rhesus macaque challenge model. We examined the pharmacokinetics and efficacy of GSK744 LA as PrEP against repeat high-dose intravaginal SHIV challenge in...

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Identifiers

PMID: 25589630
DOI: 10.1126/scitranslmed.3010298
PMCID: PMC4449736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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