Exposure to MIV-150 from a high-dose intravaginal ring results in limited emergence of drug resistance mutations in SHIV-RT infected rhesus macaques.

doi:10.1371/journal.pone.0089300

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Article

Exposure to MIV-150 from a high-dose intravaginal ring results in limited emergence of drug resistance mutations in SHIV-RT infected rhesus macaques.

PloS one - 1 Jan 2014

Hsu Mayla, Keele Brandon F, Aravantinou Meropi, Krawczyk Noa, Seidor Samantha, Abraham Ciby J, Zhang Shimin, Rodriguez Aixa, Kizima Larisa, Derby Nina, Jean-Pierre Ninochka, Mizenina Olga, Gettie Agegnehu, Grasperge Brooke, Blanchard James, Piatak Michael J, Lifson Jeffrey D, Fernández-Romero José A, Zydowsky Thomas M, Robbiani Melissa

Abstract excerpt

When microbicides used for HIV prevention contain antiretroviral drugs, there is concern for the potential emergence of drug-resistant HIV following use in infected individuals who are either unaware of their HIV infection status or who are aware but still choose to use the microbicide. Resistant virus could ultimately impact their responsiveness to treatment and/or result in subsequent transmission of...

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PMID: 24586674
DOI: 10.1371/journal.pone.0089300
PMCID: PMC3937329

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