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Article

Efficient repeated low-dose intravaginal infection with X4 and R5 SHIVs in rhesus macaque: implications for HIV-1 transmission in humans.

Virology - 25 May 2007

Tsai Lily, Trunova Nataliya, Gettie Agegnehu, Mohri Hiroshi, Bohm Rudolf, Saifuddin Mohammed, Cheng-Mayer Cecilia

Abstract excerpt

We examined the effect of inoculum dose on SHIV transmission and infection. We found that repeated low-dose intravaginal exposure with either R5-SHIV(SF162P3) or X4-SHIV(SF33A) results in infections that are blunted and rapidly controlled. Interestingly, although the transmission rate after all r...

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Identifiers

PMID: 17258783
DOI: 10.1016/j.virol.2006.12.024
PMCID: PMC1941575

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17258783-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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