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Article

Protection against rectal transmission of an emtricitabine-resistant simian/human immunodeficiency virus SHIV162p3M184V mutant by intermittent prophylaxis with Truvada.

Journal of virology - 1 Aug 2011

Cong Mian-Er, Youngpairoj Ae S, Zheng Qi, Aung Wutyi, Mitchell James, Sweeney Elizabeth, Hanson Debra L, Hendry R Michael, Dobard Charles, Heneine Walid, García-Lerma J Gerardo

Abstract excerpt

Daily preexposure prophylaxis (PrEP) with Truvada (emtricitabine [FTC] and tenofovir disoproxil fumarate [TDF]) is a novel HIV prevention strategy recently found to reduce HIV incidence among men who have sex with men. We used a macaque model of HIV transmission to investigate if Truvada maintains prophylactic efficacy against an FTC-resistant isolate containing the M184V mutation. Five macaques received a dose...

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Identifiers

PMID: 21632769
DOI: 10.1128/JVI.00843-11
PMCID: PMC3147931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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