Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Long-acting capsid inhibitor protects macaques from repeat SHIV challenges

7 Dec 2021

Abstract excerpt

Abstract Because no currently available vaccine can prevent HIV infection, pre-exposure prophylaxis (PrEP) with antiretrovirals (ARVs) is an important tool for combating the HIV pandemic1,2. Long-acting ARVs promise to build on the success of current PrEP strategies, which must be taken daily, by reducing the frequency of administration3. GS-CA1 is a small-molecule HIV capsid inhibitor with picomolar antiviral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS drug development and treatment
Share to HIV/AIDS Research and Interventions
Share to HIV Research and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34875675
DOI: 10.1038/s41586-021-04279-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Long-acting capsid inhibitor protects macaques from repeat SHIV challengesPMID 34875675Read ↗

A long-acting integrase inhibitor protects female macaques from repeated high-dose intravaginal SHIV challenge.Semantic proximity Read ↗

New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention and CureSemantic proximity Read ↗

A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges.Semantic proximity Read ↗

A single injection of crystallizable fragment domain-modified antibodies elicits durable protection from SHIV infection.Semantic proximity Read ↗

Efficient repeated low-dose intravaginal infection with X4 and R5 SHIVs in rhesus macaque: implications for HIV-1 transmission in humans.Semantic proximity Read ↗

Susceptibility to repeated, low-dose, rectal SHIVSF162P3 challenge is independent of TRIM5 genotype in rhesus macaques.Semantic proximity Read ↗

Mucosal Transmission and Induction of Simian AIDS by CCR5-Specific Simian/Human Immunodeficiency Virus SHIV <sub>SF162P3</sub>Semantic proximity Read ↗

The Nonnucleoside Reverse Transcriptase Inhibitor MIV-150 in Carrageenan Gel Prevents Rectal Transmission of Simian/Human Immunodeficiency Virus Infection in MacaquesSemantic proximity Read ↗

Simian-Human Immunodeficiency Virus SHIV.C.CH505 Persistence in ART-Suppressed Infant Macaques Is Characterized by Elevated SHIV RNA in the Gut and a High Abundance of Intact SHIV DNA in Naive CD4 + T CellsSemantic proximity Read ↗

Limited SHIV env diversification in macaques failing oral antiretroviral pre-exposure prophylaxis.Semantic proximity Read ↗

Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes.Semantic proximity Read ↗

Generation and Evaluation of Clade C Simian-Human Immunodeficiency Virus Challenge StocksSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.