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Article

Prognostic signature and clonality pattern of recurrently mutated genes in inactive chronic lymphocytic leukemia.

Blood cancer journal - 28 Aug 2015

Hurtado A M, Chen-Liang T-H, Przychodzen B, Hamedi C, Muñoz-Ballester J, Dienes B, García-Malo M D, Antón A I, de Arriba F, Teruel-Montoya R, Ortuño F J, Vicente V, Maciejewski J P, Jerez A

Abstract excerpt

An increasing numbers of patients are being diagnosed with asymptomatic early-stage chronic lymphocytic leukemia (CLL), with no treatment indication at baseline. We applied a high-throughput deep-targeted analysis, especially designed for covering widely TP53 and ATM genes, in 180 patients with inactive disease at diagnosis, to test the independent prognostic value of CLL somatic recurrent mutations. We found...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Kaplan-Meier Estimate

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

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Identifiers

PMID: 26314984
DOI: 10.1038/bcj.2015.65
PMCID: PMC4558590

Genes

ATM
NOTCH1

Provenance

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