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Article

p53 dysregulation in B-cell malignancies: More than a single gene in the pathway to hell.

Blood reviews - 1 Jul 2017

Tessoulin B, Eveillard M, Lok A, Chiron D, Moreau P, Amiot M, Moreau-Aubry A, Le Gouill S, Pellat-Deceunynck C

Abstract excerpt

TP53 deletion or mutation is frequent in B-cell malignancies and is associated with a low response rate. We describe here the p53 landscape in B-cell malignancies, from B-Acute Lymphoblastic Leukemia to Plasma Cell Leukemia, by analyzing incidence of gain or loss of function of actors both upstream and within the p53 pathway, namely MYC, RAS, ARF, MDM2, ATM and TP53. Abnormalities are not equally distributed and...

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Share to B-Lymphocytes
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MDM2 gene

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Share to Lymphoma, B-Cell

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Share to Signal Transduction

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 28284458
DOI: 10.1016/j.blre.2017.03.001

Genes

MYC
ATM
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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