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Article

The role of TP53 network in the pathogenesis of chronic lymphocytic leukemia.

International journal of clinical and experimental pathology - 1 Jan 2013

Wang Cheng, Wang Xin

Abstract excerpt

TP53 is one of the most important prognostic factors in chronic lymphocytic leukemia (CLL). Modulation of microRNAs by TP53 in CLL pathogenesis has been a hotspot. Besides, it has an intimate association with other cytogenetics and plays an important part in drug resistance of CLL. All above indicate an embedded TP53-centered network in CLL pathogenesis and prognosis. In this review, we focus on the TP53-centered...

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Topics

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Share to Gene Deletion
Share to Gene Expression Regulation, Neoplastic
Share to Leukemia, Lymphocytic, Chronic, B-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MicroRNAs

Share to Mutation

Share to Signal Transduction

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 23826404
PMCID: PMC3693188

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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