Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Central role of SREBP-2 in the pathogenesis of osteoarthritis.

PloS one - 1 Jan 2012

Kostopoulou Fotini, Gkretsi Vasiliki, Malizos Konstantinos N, Iliopoulos Dimitrios, Oikonomou Pagona, Poultsides Lazaros, Tsezou Aspasia

Abstract excerpt

BACKGROUND: Recent studies have implied that osteoarthritis (OA) is a metabolic disease linked to deregulation of genes involved in lipid metabolism and cholesterol efflux. Sterol Regulatory Element Binding Proteins (SREBPs) are transcription factors regulating lipid metabolism with so far no association with OA. Our aim was to test the hypothesis that SREBP-2, a gene that plays a key role in cholesterol...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aggrecans
Share to Collagen Type II
Share to Hydroxycholesterols

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydroxymethylglutaryl CoA Reductases

Share to Osteoarthritis

Share to Peptides, Cyclic

Share to Smad3 Protein

Share to Sterol Regulatory Element Binding Protein 2

Source

Open in PubMed Open full text

Identifiers

PMID: 22662110
DOI: 10.1371/journal.pone.0035753
PMCID: PMC3360703

Genes

HMGCR
ACAN
ITGAV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Central role of SREBP-2 in the pathogenesis of osteoarthritis.PMID 22662110Read ↗

MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytesSemantic proximity Read ↗

Association between single nucleotide polymorphisms of sterol regulatory element binding protein-2 gene and risk of knee osteoarthritis in a Chinese Han population.Semantic proximity Read ↗

Research progress of SREBP and its role in the pathogenesis of autoimmune rheumatic diseasesSemantic proximity Read ↗

Runx2 plays a central role in Osteoarthritis developmentSemantic proximity Read ↗

Runx3 alleviates osteoarthritis through microRNA regulating multiple inflammation-related pathwaysSemantic proximity Read ↗

Circular RNA circARPC1B functions as a stabilisation enhancer of Vimentin to prevent high cholesterol‐induced articular cartilage degenerationSemantic proximity Read ↗

Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymesSemantic proximity Read ↗

Adipokine Signaling Pathways in OsteoarthritisSemantic proximity Read ↗

Significant association of SREBP-2 genetic polymorphisms with avascular necrosis in the Korean population.Semantic proximity Read ↗

Regulation of Cartilage Development and Diseases by Transcription FactorsSemantic proximity Read ↗

Sterol-regulatory element-binding protein (SREBP)-2 contributes to polygenic hypercholesterolaemia.Semantic proximity Read ↗

Development of novel osteoarthritis therapy by targeting AMPK-β-catenin-Runx2 signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.