Article
Adult cartilage-specific peroxisome proliferator-activated receptor gamma knockout mice exhibit the spontaneous osteoarthritis phenotype.
The American journal of pathology - 1 Apr 2013
Vasheghani Faezeh, Monemdjou Roxana, Fahmi Hassan, Zhang Yue, Perez Gemma, Blati Meryem, St-Arnaud René, Pelletier Jean-Pierre, Beier Frank, Martel-Pelletier Johanne, Kapoor Mohit
Abstract excerpt
Osteoarthritis (OA) is an age-related progressive degenerative joint disease. Peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor, is suggested as an attractive therapeutic target to counteract degradative mechanisms associated with OA. Studies suggest that activation of PPARγ by its agonists can reduce the synthesis of OA catabolic and inflammatory factors and the development of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.