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Article

Adult cartilage-specific peroxisome proliferator-activated receptor gamma knockout mice exhibit the spontaneous osteoarthritis phenotype.

The American journal of pathology - 1 Apr 2013

Vasheghani Faezeh, Monemdjou Roxana, Fahmi Hassan, Zhang Yue, Perez Gemma, Blati Meryem, St-Arnaud René, Pelletier Jean-Pierre, Beier Frank, Martel-Pelletier Johanne, Kapoor Mohit

Abstract excerpt

Osteoarthritis (OA) is an age-related progressive degenerative joint disease. Peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor, is suggested as an attractive therapeutic target to counteract degradative mechanisms associated with OA. Studies suggest that activation...

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Source

Identifiers

PMID: 23375622
DOI: 10.1016/j.ajpath.2012.12.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23375622-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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