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Article

Fstl1 Antagonizes BMP Signaling and Regulates Ureter Development

2 Apr 2012

Abstract excerpt

Bone morphogenetic protein (BMP) signaling pathway plays important roles in urinary tract development although the detailed regulation of its activity in this process remains unclear. Here we report that follistatin-like 1 (Fstl1), encoding a secreted extracellular glycoprotein, is expressed in developing ureter and antagonizes BMP signaling activity. Mouse embryos carrying disrupted Fstl1 gene displayed...

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PMID: 22485132
DOI: 10.1371/journal.pone.0032554

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