Article
Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells.
Proceedings of the National Academy of Sciences of the United States of America - 27 Jan 2015
Bartesaghi Stefano, Graziano Vincenzo, Galavotti Sara, Henriquez Nick V, Betts Joanne, Saxena Jayeta, Minieri Valentina, A Deli, Karlsson Anna, Martins L Miguel, Capasso Melania, Nicotera Pierluigi, Brandner Sebastian, De Laurenzi Vincenzo, Salomoni Paolo
Abstract excerpt
Alterations of mitochondrial metabolism and genomic instability have been implicated in tumorigenesis in multiple tissues. High-grade glioma (HGG), one of the most lethal human neoplasms, displays genetic modifications of Krebs cycle components as well as electron transport chain (ETC) alterations. Furthermore, the p53 tumor suppressor, which has emerged as a key regulator of mitochondrial respiration at the...
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