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Article

CD133 Is a Marker of Bioenergetic Stress in Human Glioma

5 Nov 2008

Abstract excerpt

Mitochondria dysfunction and hypoxic microenvironment are hallmarks of cancer cell biology. Recently, many studies have focused on isolation of brain cancer stem cells using CD133 expression. In this study, we investigated whether CD133 expression is regulated by bioenergetic stresses affecting mitochondrial functions in human glioma cells. First, we determined that hypoxia induced a reversible up-regulation of...

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PMID: 18985161
DOI: 10.1371/journal.pone.0003655

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