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Article

Efficacy of statins on sirtuin 1 and endothelial nitric oxide synthase expression: the role of sirtuin 1 gene variants in human coronary atherosclerosis.

Clinical and experimental pharmacology & physiology - 1 Apr 2015

Kilic Ulkan, Gok Ozlem, Elibol-Can Birsen, Uysal Omer, Bacaksiz Ahmet

Abstract excerpt

Statins are 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and are used to reduce the risk of coronary artery disease (CAD) due to their pleiotropic effects. Recently, greater focus has been placed on the role of sirtuin 1 (SIRT1) in cardiovascular disease research. However, insufficient data exist on the relationships between statins, SIRT1 protein levels, and SIRT1 gene variants. In the present...

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Source

Identifiers

PMID: 25582759
DOI: 10.1111/1440-1681.12362

Genes

SIRT1
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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