SIRT1 gene polymorphisms affect the protein expression in cardiovascular diseases.

doi:10.1371/journal.pone.0090428

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Article

SIRT1 gene polymorphisms affect the protein expression in cardiovascular diseases.

PloS one - 1 Jan 2014

Kilic Ulkan, Gok Ozlem, Bacaksiz Ahmet, Izmirli Muzeyyen, Elibol-Can Birsen, Uysal Omer

Abstract excerpt

Cardiovascular disease (CVD), the leading cause of death worldwide, is related to gene-environment interactions due to epigenetic factors. SIRT1 protein and its downstream pathways are critical for both normal homeostasis and protection from CVD-induced defects. The aim of this study was to investigate the association between SIRT1 single nucleotide polymorphisms (SNPs) (rs7895833 A>G in the promoter region,...

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PMID: 24587358
DOI: 10.1371/journal.pone.0090428
PMCID: PMC3938716

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SIRT1

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