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Article

Computational and biochemical design of a nanopore cleavable by a cancer-secreted enzyme.

Chembiochem : a European journal of chemical biology - 9 Feb 2015

Pittel Ilya, Alper Naomi, Yonai Shiran, Basch Shani, Blum Leah, Bachur Ayelet, Paas Yoav

Abstract excerpt

Many proteinaceous macromolecules selectively transport substrates across lipid bilayers and effectively serve as gated nanopores. Here, we engineered cleavage-site motifs for human matrix metalloprotease 7 (MMP-7) into the extracellular and pore-constricting loops of OprD, a bacterial substrate-specific transmembrane channel. Concurrent removal of two extracellular loops allowed MMP-7 to access and hydrolyze a...

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Identifiers

PMID: 25581099
DOI: 10.1002/cbic.201402378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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