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Article

Switching Cytolytic Nanopores into Antimicrobial Fractal Ruptures by a Single Side Chain Mutation.

ACS nano - 22 Jun 2021

Hammond Katharine, Cipcigan Flaviu, Al Nahas Kareem, Losasso Valeria, Lewis Helen, Cama Jehangir, Martelli Fausto, Simcock Patrick W, Fletcher Marcus, Ravi Jascindra, Stansfeld Phillip J, Pagliara Stefano, Hoogenboom Bart W, Keyser Ulrich F, Sansom Mark S P, Crain Jason, Ryadnov Maxim G

Abstract excerpt

Disruption of cell membranes is a fundamental host defense response found in virtually all forms of life. The molecular mechanisms vary but generally lead to energetically favored circular nanopores. Here, we report an elaborate fractal rupture pattern induced by a single side-chain mutation in ultrashort (8-11-mers) helical peptides, which otherwise form transmembrane pores. In contrast to known mechanisms, this...

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PMID: 33885289
DOI: 10.1021/acsnano.1c00218
PMCID: PMC8219408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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