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Article

The origin of CDR H3 structural diversity.

Structure (London, England : 1993) - 3 Feb 2015

Weitzner Brian D, Dunbrack Roland L, Gray Jeffrey J

Abstract excerpt

Antibody complementarity determining region (CDR) H3 loops are critical for adaptive immunological functions. Although the other five CDR loops adopt predictable canonical structures, H3 conformations have proven unclassifiable, other than an unusual C-terminal "kink" present in most antibodies. To determine why the majority of H3 loops are kinked and to learn whether non-antibody proteins have loop structures...

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Identifiers

PMID: 25579815
DOI: 10.1016/j.str.2014.11.010
PMCID: PMC4318709

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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