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Non-H3 CDR template selection in antibody modeling through machine learning

2018-06-20

Abstract excerpt

Antibodies are proteins generated by the adaptive immune system to recognize and counteract a plethora of pathogens through specific binding. This adaptive binding is mediated by structural diversity in the six complementary determining region (CDR) loops (H1, H2, H3, L1, L2 and L3), which also makes accurate structural modeling of CDRs challenging. Both homology and de novo modeling approaches have been used; to...

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Literature Corpus work
3b21d93c-fbd3-5b9a-af90-c29bf9ab3be4
DOI
10.7287/peerj.preprints.26996v1
Open publication

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Non-H3 CDR template selection in antibody modeling through machine learningDOI 10.7287/peerj.preprints.26996v1
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