The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections.

doi:10.1007/s10096-014-2309-2

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Article

The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 May 2015

Jaeger Martin, van der Lee Robin, Cheng Shih-Chin, Johnson Melissa D, Kumar Vinod, Ng Aylwin, Plantinga Theo S, Smeekens Sanne P, Oosting Marije, Wang Xinhui, Barchet Winfried, Fitzgerald Kate, Joosten Leo A B, Perfect John R, Wijmenga Cisca, van de Veerdonk Frank L, Huynen Martijn A, Xavier Ramnik J, Kullberg Bart-Jan, Netea Mihai G

Abstract excerpt

The induction of host defense against Candida species is initiated by recognition of the fungi by pattern recognition receptors and activation of downstream pathways that produce inflammatory mediators essential for infection clearance. In this study, we present complementary evidence based on transcriptome analysis, genetics, and immunological studies in knockout mice and humans that the cytosolic RIG-I-like...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25579795
DOI: 10.1007/s10096-014-2309-2
PMCID: PMC5084092

Genes

IFIH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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