Article
Phosphorylation of a chronic pain mutation in the voltage-gated sodium channel Nav1.7 increases voltage sensitivity.
The Journal of biological chemistry - 1 Jan 2000
Kerth Clara M, Hautvast Petra, Körner Jannis, Lampert Angelika, Meents Jannis E
Abstract excerpt
Mutations in voltage-gated sodium channels (Navs) can cause alterations in pain sensation, such as chronic pain diseases like inherited erythromelalgia. The mutation causing inherited erythromelalgia, Nav1.7 p.I848T, is known to induce a hyperpolarized shift in the voltage dependence of activatio...
Topics
- Amino Acid Substitution
- Binding Sites
- Chronic Pain
- Erythromelalgia
- Gene Expression
- HEK293 Cells
- Humans
- Ion Channel Gating
- Isoleucine
- Membrane Potentials
- Models, Molecular
- Mutation