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Article

Pain disorders and erythromelalgia caused by voltage-gated sodium channel mutations.

Current neurology and neuroscience reports - 1 Feb 2012

Dabby Ron

Abstract excerpt

Voltage-gated sodium channels play a pivotal role in pain transmission. They are widely expressed in nociceptive neurons, and participate in the generation of action potentials. Alteration in ionic conduction of these channels causes abnormal electrical firing, thus renders neurons hyperexcitable. So far, mutations in the Na(v)1.7 sodium channel, which is expressed in the dorsal root ganglia cells and sympathetic...

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Identifiers

PMID: 21984269
DOI: 10.1007/s11910-011-0233-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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