Article
Evidence of genotypic resistance diversity of archived and circulating viral strains in blood and semen of pre-treated HIV-infected men.
AIDS (London, England) - 20 Feb 2004
Ghosn Jade, Viard Jean-Paul, Katlama Christine, de Almeida Marta, Tubiana Roland, Letourneur Franck, Aaron Laurent, Goujard Cécile, Salmon Dominique, Leruez-Ville Marianne, Rouzioux Christine, Chaix Marie-Laure
Abstract excerpt
OBJECTIVE: To study the genetic diversity of drug-resistant HIV strains present in blood and in semen, especially those archived in peripheral blood mononuclear cells (PBMC) and non-sperm cells (NSC). METHODS: Paired blood and semen samples were collected from twenty heavily pre-treated HIV-infected men. HIV RNA in blood plasma (BP) and seminal plasma (SP), as well as proviral DNA in PBMC and NSC were quantified...
Topics
- Adult
- Cross-Sectional Studies
- DNA, Viral
- Drug Resistance, Viral
- Genetic Variation
- Genotype
- HIV Infections
- HIV Protease
- HIV Reverse Transcriptase
- HIV-1