Article
HIV-1 resistant strains acquired at the time of primary infection massively fuel the cellular reservoir and persist for lengthy periods of time.
AIDS (London, England) - 9 Jan 2006
Ghosn Jade, Pellegrin Isabelle, Goujard Cécile, Deveau Christiane, Viard Jean-Paul, Galimand Julie, Harzic Martine, Tamalet Catherine, Meyer Laurence, Rouzioux Christine, Chaix Marie-Laure
Abstract excerpt
OBJECTIVE: Characterization of the early establishment of the viral reservoir in patients acquiring resistant strains at primary HIV-1 infection (PHI), and longitudinal analysis of resistance mutations in circulating virions and intracellular HIV strains. PATIENTS AND METHODS: Drug-resistance was compared between HIV RNA and peripheral blood mononuclear cell (PBMC)-HIV DNA at the time of PHI in 44 patients...
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