Article
Expression and regulation of interferon-related development regulator-1 in cystic fibrosis neutrophils.
American journal of respiratory cell and molecular biology - 1 Jan 2013
Hector Andreas, Kormann Michael, Kammermeier Julia, Burdi Sofia, Marcos Veronica, Rieber Nikolaus, Mays Lauren, Illig Thomas, Klopp Norman, Falkenstein Fabian, Kappler Matthias, Riethmueller Joachim, Graepler-Mainka Ute, Stern Martin, Eickmeier Olaf, Serve Friederike, Zielen Stefan, Döring Gerd, Griese Matthias, Hartl Dominik
Abstract excerpt
A genome-wide association study identified interferon-related development regulator-1 (IFRD1), a protein expressed by neutrophils, as a key modifier gene in cystic fibrosis (CF) lung disease. Here, we investigated the expression and regulation of IFRD1 in CF neutrophils. IFRD1 expression was quantified in peripheral blood and airway neutrophils from patients with CF, patients with non-CF lung disease, and healthy...
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